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008 170529s2017 enka||||||||||001 0|eng|c
015 GBB755080|2bnb
020 9780198749691|qpbk
020 0198749694|qpbk
041 eng
082 04 615.19|223
084 Pmca|2kssb/8 (machine generated)
092 0 615|bengelska
100 1 Patrick, Graham L.|4aut
245 13 An introduction to medicinal chemistry /|cGraham Patrick
250 6. edition
264 1 Oxford :|bOxford University Press,|c2017
264 1 Oxford :|bOxford University Press,|c2017
300 volume (xxxi, 877 s.)|billustrationer
336 text|btxt|2rdacontent
336 still image|bsti|2rdacontent
337 unmediated|bn|2rdamedia
338 volume|bnc|2rdacarrier
500 Previous edition: 2013
504 Includes bibliographical references and index
505 8 1: Drugs and drug targets : an overview -- Part A: Drug
targets : structure and function -- 2: Protein structure
and function -- 3: Enzymes: structure and function -- 4:
Receptors: structure and function -- 5: Receptors and
signal transduction -- 6: Nucleic acids: structure and
function --Part B: Pharmacodynamics and pharmacokinetics -
- 7: Enzymes as drug targets -- 8: Receptors as drug
targets -- 9: Nucleic acids as drug targets -- 10:
Miscellaneous drug targets -- 11: Pharmacokinetics and
related topics -- Case study 1: Statins -- Part C: Drug
discovery, design, and development -- 12: Drug discovery:
finding a lead -- 13: Drug design: optimizing target
interactions -- 14: Drug design: optimizing access to the
target -- 15: Getting the drug to market -- Case study 2:
The design of ACE inhibitors -- Case study 3: Artemisinin
and related antimalarial drugs -- Case study 4: The design
of oxamniquine --Part D: Tools of the trade -- 16:
Combinatorial synthesis -- 17: Computers in medicinal
chemistry -- 18: Quantitative structure-activity
relationships (QSAR) -- Case study 5: De novo design of a
thymidylate synthase inhibitor -- Part E: Selected topics
in medicinal chemistry -- 19: Antibacterial agents -- 20:
Antiviral agents -- 21: Anticancer agents -- 22:
Cholinergics, anticholinergics, and anticholinesterases --
23: Drugs acting on the adrenergic nervous system -- 24:
Opioid analgesics -- 25: Antiulcer agents -- 26:
Cardiovascular drugs -- Case study 6: Steroidal anti-
inflammatory agents -- Case Study 7: Design of a novel
antidepressant -- Case Study 8: The design and development
of aliskiren -- Case Study 9: Factor Xa inhibitors -- Case
Study 10: Reversible inhibitors of HCV NS3-4A protease --
Appendices
520 For many people, taking some form of medication is part of
everyday life, whether for mild or severe illness, acute
or chronic disease, to target infection or to relieve
pain. However for most it remains a mystery as to what
happens once the drug has been taken into the body: how do
the drugs actually work? Furthermore, by what processes
are new drugs discovered and brought to market? An
Introduction to Medicinal Chemistry, sixth edition,
provides an accessible and comprehensive account of this
fascinating multidisciplinary field. Assuming little prior
knowledge, the text is ideal for those studying the
subject for the first time. Part one of the book
introduces the principles of drug action via targets such
as receptors and enzymes. The book goes on to explore how
drugs work at the molecular level (pharmacodynamics), and
the processes involved in ensuring a drug meets its target
(pharmacokinetics). Further sections cover the processes
by which drugs are discovered and designed, and what has
to happen before a drug can be made available to the
public. The book concludes with a selection of current
topics in medicinal chemistry, and a discussion of various
key drug groups. The subject is brought to life throughout
by engaging case studies highlighting particular drugs and
the stories behind their discovery and development
599 Imported from: z3950cat.bl.uk:9909/BNB03U (Do not remove)
650 0 Pharmaceutical chemistry
650 2 Chemistry, Pharmaceutical
650 7 Farmaceutisk kemi|2sao
650 7 Medicinsk kemi|2sao
907 00 190925
